Professor Edmund Crampin

Research Interests

  • Biomedical Engineering
  • Computational Physiology
  • Mathematical Biology
  • Systems Biology

Personal webpage

http://www.bme.unimelb.edu.au/systems-biology/

Biography

Professor Edmund Crampin is the Rowden White Chair of Systems and Computational Biology at the University of Melbourne. Edmund directs the Systems Biology Lab at the Melbourne School of Engineering, and is Adjunct Professor in the Faculties of Science (Mathematics & Statistics) and Medicine, Dentistry and Health Sciences (School of Medicine). Edmund's research uses mathematical and computer modeling to investigate regulatory processes and pathways underlying complex human diseases. A feature of his group's research is to include cell and tissue structural information in mechanistic models of the biochemical networks that control cell function. Current research projects include using mathematical models of heart cells to understand the development of heart disease; developing computational approaches to study the network of genetic interactions underlying breast and skin cancers; and modelling the regulation of transepithelial fluid secretion in the salivary glands and the lung. The group also contributes to projects in biosensor design, biomarker identification, and development of computational tools and standards for integrative systems biology. After graduating with a BSc (Hons) in Physics from Imperial College London, Edmund completed a DPhil in Applied Mathematics at the University of Oxford. He was subsequently elected to a Junior Research Fellowship at Brasenose College Oxford and in 2001 he won a Research Fellowship from the Wellcome Trust to study mathematical models of heart disease. In 2003 Edmund moved to the University of Auckland to continue this work at the Auckland Bioengineering Institute, where he established the Systems Biology group. Edmund moved to the University of Melbourne in 2013 to take up the Chair of Systems and Computational Biology.

Recent Publications

  1. Cui J, Faria M, BjÖrnmalm M, Ju Y, Suma T, Gunawan S, Richardson J, Heidari H, Bals S, Crampin E, Caruso F. A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions.. Langmuir. American Chemical Society. 2016.
  2. Budden DM, Crampin E. Information theoretic approaches for inference of biological networks from continuous-valued data. BMC SYSTEMS BIOLOGY. Biomed Central. 2016, Vol. 10.
  3. Gawthrop P, Crampin E. Modular bond-graph modelling and analysis of biomolecular systems. IET SYSTEMS BIOLOGY. Institution of Engineering and Technology. 2016, Vol. 10, Issue 5.
  4. Sharp K, Crampin E, Sneyd J. A spatial model of fluid recycling in the airways of the lung. JOURNAL OF THEORETICAL BIOLOGY. Academic Press. 2015, Vol. 382.
  5. Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin E, Soeller C. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLOS COMPUTATIONAL BIOLOGY. Public Library of Science. 2015, Vol. 11, Issue 9.
  6. Gawthrop P, Cursons J, Crampin E. Hierarchical bond graph modelling of biochemical networks. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2015, Vol. 471, Issue 2184.
  7. Budden D, Hurley D, Crampin E. Modelling the conditional regulatory activity of methylated and bivalent promoters. EPIGENETICS & CHROMATIN. Biomed Central. 2015, Vol. 8.
  8. Hurley D, Cursons J, Wang YK, Budden D, Print CG, Crampin E. NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks. BIOINFORMATICS. Oxford University Press. 2015, Vol. 31, Issue 2.
  9. Detchokul S, Elangovan A, Crampin E, Davis M, Frauman A. Network analysis of an in vitro model of androgen-resistance in prostate cancer. BMC CANCER. Biomed Central. 2015, Vol. 15.
  10. Budden D, Crampin E. Predictive modelling of gene expression from transcriptional regulatory elements. BRIEFINGS IN BIOINFORMATICS. Oxford University Press. 2015, Vol. 16, Issue 4.
  11. Tran K, Loiselle DS, Crampin E. Regulation of cardiac cellular bioenergetics: mechanisms and consequences.. Physiol Rep. 2015, Vol. 3, Issue 7.
  12. Cursons J, Gao J, Hurley D, Print CG, Dunbar PR, Jacobs MD, Crampin E. Regulation of ERK-MAPK signaling in human epidermis. BMC SYSTEMS BIOLOGY. Biomed Central. 2015, Vol. 9.
  13. Neal ML, Carlson BE, Thompson CT, James RC, Kim KG, Tran K, Crampin E, Cook DL, Gennari JH. Semantics-Based Composition of Integrated Cardiomyocyte Models Motivated by Real-World Use Cases. PLOS ONE. Public Library of Science. 2015, Vol. 10, Issue 12.
  14. Cursons J, Angel CE, Hurley D, Print CG, Dunbar PR, Jacobs MD, Crampin E. Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis. GIGASCIENCE. Biomed Central. 2015, Vol. 4.
  15. Cursons J, Leuchowius K, Waltham M, Tomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin E, Street I, Davis M, Thompson E. Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines. CELL COMMUNICATION AND SIGNALING. Biomed Central. 2015, Vol. 13.

Edmund Crampin

University of Melbourne
3010 Australia

T: +61 3 9035 8989
E: edmund.crampin@unimelb.edu.au


View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile