Professor Edmund Crampin

Research interests

  • Biomedical Engineering
  • Mathematical Biology
  • Systems Biology

Personal webpage


Professor Edmund Crampin is Rowden White Chair of Systems Biology at the University of Melbourne.

Edmund directs the Systems Biology Lab at the School of Mathematics and Statistics and the Department of Biomedical Engineering at the Melbourne School of Engineering, and is Adjunct Professor in the Faculty of Medicine, Dentistry and Health Sciences (School of Medicine). The Systems Biology Lab is a multi-team collaborative group developing mathematical and computer modeling approaches to investigate regulatory processes and biophysical mechanisms underlying complex human diseases.

Current projects include modelling heart cells to understand the development of heart disease; modelling interactions between cells and nanoparticles; and computational approaches to study the network of genetic interactions underlying breast and skin cancer. The group also develops computational tools and standards for integrative systems biology.

Biographical details:
Edmund graduated with a BSc (Hons) in Physics from Imperial College London, and completed a DPhil in Applied Mathematics at the University of Oxford. Edmund’s thesis topic was on biological pattern formation, and his thesis advisor was Professor Philip Maini FRS. Edmund was subsequently elected to a Junior Research Fellowship at Brasenose College Oxford and in 2001 he was awarded a Research Fellowship from the Wellcome Trust to study mathematical models of heart disease, under the guidance of Professor Denis Noble FRS. In 2003 Edmund established the Systems Biology group at the Auckland Bioengineering Institute, in collaboration with Institute director Professor Peter Hunter FRS. Edmund moved to the University of Melbourne in 2013 to take up the Chair of Systems Biology.

Recent publications

  1. Ghosh S, Crampin E, Hanssen E, Rajagopal V. A computational study of the role of mitochondrial organization on cardiac bioenergetics. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Institute of Electrical and Electronics Engineers. 2017. DOI: 10.1109/EMBC.2017.8037413
  2. Gawthrop P, Siekmann I, Kameneva T, Saha S, Ibbotson M, Crampin E. Bond graph modelling of chemoelectrical energy transduction. IET SYSTEMS BIOLOGY. Institution of Engineering and Technology. 2017, Vol. 11, Issue 5. DOI: 10.1049/iet-syb.2017.0006
  3. Jarosz J, Ghosh S, Delbridge L, Petzer A, Hickey AJR, Crampin E, Hanssen E, Rajagopal V. Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. American Physiological Society. 2017, Vol. 312, Issue 2. DOI: 10.1152/ajpcell.00298.2016
  4. Glass J, Chen L, Alcantara S, Crampin E, Thurecht KJ, De Rose R, Kent S. Charge Has a Marked Influence on Hyperbranched Polymer Nanoparticle Association in Whole Human Blood. ACS MACRO LETTERS. American Chemical Society. 2017, Vol. 6, Issue 6. DOI: 10.1021/acsmacrolett.7b00229
  5. Gawthrop P, Crampin E. Energy-based analysis of biomolecular pathways. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2017, Vol. 473, Issue 2202. DOI: 10.1098/rspa.2016.0825
  6. Tran K, Han J-C, Crampin E, Taberner AJ, Loiselle DS. Experimental and modelling evidence of shortening heat in cardiac muscle. JOURNAL OF PHYSIOLOGY-LONDON. Wiley-Blackwell Publishing. 2017, Vol. 595, Issue 19. DOI: 10.1113/JP274680
  7. Cui J, Faria M, Bjornmalm A, Ju Y, Suma T, Gunawan S, Richardson J, Heidar H, Bals S, Crampin E, Caruso F. A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions. LANGMUIR. American Chemical Society. 2016, Vol. 32, Issue 47. DOI: 10.1021/acs.langmuir.6b01634
  8. Budden D, Crampin E. Distributed gene expression modelling for exploring variability in epigenetic function. BMC BIOINFORMATICS. Biomed Central. 2016, Vol. 17. DOI: 10.1186/s12859-016-1313-1
  9. Budden D, Crampin E. Information theoretic approaches for inference of biological networks from continuous-valued data. BMC SYSTEMS BIOLOGY. Biomed Central. 2016, Vol. 10. DOI: 10.1186/s12918-016-0331-y
  10. Siekmann I, Fackrell M, Crampin E, Taylor P. Modelling modal gating of ion channels with hierarchical Markov models. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2016, Vol. 472, Issue 2192. DOI: 10.1098/rspa.2016.0122
  11. Gawthrop P, Crampin E. Modular bond-graph modelling and analysis of biomolecular systems. IET SYSTEMS BIOLOGY. Institution of Engineering and Technology. 2016, Vol. 10, Issue 5. DOI: 10.1049/iet-syb.2015.0083
  12. Tran K, Han J-C, Taberner AJ, Barrett CJ, Crampin E, Loiselle DS. Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. American Physiological Society. 2016, Vol. 311, Issue 3. DOI: 10.1152/ajpheart.00396.2016
  13. Andrews M, Cursons J, Hurley D, Anaka M, Cebon J, Behren A, Crampin E. Systems analysis identifies miR-29b regulation of invasiveness in melanoma. MOLECULAR CANCER. Biomed Central. 2016, Vol. 15. DOI: 10.1186/s12943-016-0554-y
  14. Sharp K, Crampin E, Sneyd J. A spatial model of fluid recycling in the airways of the lung. JOURNAL OF THEORETICAL BIOLOGY. Academic Press. 2015, Vol. 382. DOI: 10.1016/j.jtbi.2015.06.050
  15. Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin E, Soeller C. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLOS COMPUTATIONAL BIOLOGY. Public Library of Science. 2015, Vol. 11, Issue 9. DOI: 10.1371/journal.pcbi.1004417

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile