Professor Edmund Crampin

Research Interests

  • Biomedical Engineering
  • Mathematical Biology
  • Systems Biology

Personal webpage

http://edmundcrampin.wordpress.com

Biography

Professor Edmund Crampin joined the University of Melbourne in 2013 to take up the Rowden White Chair of Systems and Computational Biology. Edmund directs the Systems Biology Lab at the School of Mathematics and Statistics and the Melbourne School of Engineering, and is Adjunct Professor in the Faculty of Medicine, Dentistry and Health Sciences (School of Medicine). Edmund's research uses mathematical and computer modeling to investigate regulatory processes and pathways underlying complex human diseases. Current and recent research projects include using mathematical models of heart cells to understand the development of heart disease; developing computational approaches to study the network of genetic interactions underlying breast and skin cancers; systems biology approaches in nano medicine, and modelling the regulation of transepithelial fluid secretion in the salivary glands and the lung. His group has also contributed to projects in biosensor design, biomarker identification, and is deeply involved in the development of computational tools and standards for integrative systems biology. After graduating with a BSc (Hons) in Physics from Imperial College London, Edmund completed a DPhil in Applied Mathematics at the University of Oxford. He was subsequently elected to a Junior Research Fellowship at Brasenose College Oxford and in 2001 he won a Research Fellowship from the Wellcome Trust to study mathematical models of heart disease. In 2003 Edmund moved to the University of Auckland to continue this work at the Auckland Bioengineering Institute, where he established the Systems Biology group. Edmund moved to the University of Melbourne in 2013 to take up the Chair of Systems and Computational Biology.

Recent Publications

  1. Jarosz J, Ghosh S, Delbridge L, Petzer A, Hickey AJR, Crampin E, Hanssen E, Rajagopal V. Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy.. Am J Physiol Cell Physiol. American Physiological Society. 2017, Vol. 312, Issue 2.
  2. Cui J, Faria M, Bjornmalm A, Ju Y, Suma T, Gunawan S, Richardson J, Heidar H, Bals S, Crampin E, Caruso F. A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions. LANGMUIR. American Chemical Society. 2016, Vol. 32, Issue 47.
  3. Budden D, Crampin E. Distributed gene expression modelling for exploring variability in epigenetic function. BMC BIOINFORMATICS. Biomed Central. 2016, Vol. 17.
  4. Budden D, Crampin E. Information theoretic approaches for inference of biological networks from continuous-valued data. BMC SYSTEMS BIOLOGY. Biomed Central. 2016, Vol. 10.
  5. Siekmann I, Fackrell M, Crampin E, Taylor P. Modelling modal gating of ion channels with hierarchical Markov models. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2016, Vol. 472, Issue 2192.
  6. Gawthrop P, Crampin E. Modular bond-graph modelling and analysis of biomolecular systems. IET SYSTEMS BIOLOGY. Institution of Engineering and Technology. 2016, Vol. 10, Issue 5.
  7. Tran K, Han J-C, Taberner AJ, Barrett CJ, Crampin E, Loiselle DS. Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. American Physiological Society. 2016, Vol. 311, Issue 3.
  8. Andrews M, Cursons J, Hurley D, Anaka M, Cebon J, Behren A, Crampin E. Systems analysis identifies miR-29b regulation of invasiveness in melanoma. MOLECULAR CANCER. Biomed Central. 2016, Vol. 15.
  9. Sharp K, Crampin E, Sneyd J. A spatial model of fluid recycling in the airways of the lung. JOURNAL OF THEORETICAL BIOLOGY. Academic Press. 2015, Vol. 382.
  10. Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin E, Soeller C. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLOS COMPUTATIONAL BIOLOGY. Public Library of Science. 2015, Vol. 11, Issue 9.
  11. Gawthrop P, Cursons J, Crampin E. Hierarchical bond graph modelling of biochemical networks. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2015, Vol. 471, Issue 2184.
  12. Budden D, Hurley D, Crampin E. Modelling the conditional regulatory activity of methylated and bivalent promoters. EPIGENETICS & CHROMATIN. Biomed Central. 2015, Vol. 8.
  13. Hurley D, Cursons J, Wang YK, Budden D, Print CG, Crampin E. NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks. BIOINFORMATICS. Oxford University Press. 2015, Vol. 31, Issue 2.
  14. Detchokul S, Elangovan A, Crampin E, Davis M, Frauman A. Network analysis of an in vitro model of androgen-resistance in prostate cancer. BMC CANCER. Biomed Central. 2015, Vol. 15.
  15. Budden D, Crampin E. Predictive modelling of gene expression from transcriptional regulatory elements. BRIEFINGS IN BIOINFORMATICS. Oxford University Press. 2015, Vol. 16, Issue 4.

Edmund Crampin

University of Melbourne
3010 Australia

T: +61 3 9035 8989
E: edmund.crampin@unimelb.edu.au


View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile